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We found that IL-13 stimulated the PI3K and AKT pathway in VTA slices, which are known to regulate HCN channel, a critical modulator of the firing of VTA DA neurons
In addition to altered T cells subpopulation (significantly more Th1 and Th17 cells), increased proinflammatory cytokines such as IFN-, IL2, IL6, TNF-, MCP-1, and MIP-1 also point to the role of an autoimmune reaction in PD pathogenesis [210, 211]
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