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A 2008 study by economist Michael Lovenheim looked at casual smuggling of cigarettes and found that the percentage of cigarette consumers who smuggle is between 13 and 25 percent

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Studies of this phenomenon have shown that macrophages are activated by factors such as cigarette smoke extracts and release inflammatory mediators such as TNF-, CXCL1, CXCL8, CCL2, leukotriene (LT) B4 and reactive oxygen species (ROS), etc., which mediate the inflammatory response (14)

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