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Wean: wean by 10% of the maximum stabilizing dose Example: Infant GA 38 weeks stabilized on 0.07 mg/kg x 3.2 kg = 0.224 mg 0.07 mg/kg x 10% = 0.007 mg/kg = weaning increment, 3.2 kg = dosing weight Step 1: 0.063 mg/kg Step 2: 0.056 mg/kg Step 3: 0.049 mg/kg Step 7: 0.021 mg/kg Step 8: 0.014 mg/kg discontinue Monitor for 24-48 hours after discontinuing morphine prior to discharge Methadone An option for pharmacotherapy in institutions where feasible Pros Longer half-life

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