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Furthermore, PG and VG do not cross the airway membranes and, when inhaled in large amounts, can induce hyperosmotic stress which may further induce both proinflammatory responses as well as cell stress responses [64], [65]
The American Journal of Public Health found that between 2000 and 2018, the percentage of car crash deaths in the United States involving cannabis doubled from 9% to 21.5% and the percentage of deaths involving both cannabis and alcohol have more than doubled from 4.8% to 10.3%
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