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Rachael Joyner Mar 25, 2024 3 min read Using an Adaptive Treatment regimen to guide tobacco use pharmacotherapy by Rachael Joyner, NP, FNP-BC, APRN | Nurse Practitioner With several medication options for treatment of tobacco dependence, I am often asked by patients and other healthcare providers, How do I pick the right medication? High quality evidence shows that varenicline (generic Chantix) and combination nicotine replacement therapy (NRT), such as nicotine patch plus nicotine gum or lozenge, are the most effective smoking cessation medications