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Here are some potential side effects of nicotine patches: skin reaction at the patch application site, like irritation, burning, or redness (most commonside effect) headache dizziness nausea racing or irregular heartbeat vivid dreams insomnia or disturbed sleep muscle aches or stiffness mild to moderate allergic reactions, such as rash or hives (rare) The best place to put on a nicotine patch to ensure it stays in place is typically on a clean, dry, and hairless area of skin