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Our findings reveal a slight increase in global LCAS burden, with DALYs reaching 2,061,113 (95% UI: 1,838,5882,281,339) in 2021, predominantly driven by males (e.g., Central Europe male ASMR: 4.0 vs

Winniford MD, Wheelan KR, Kremers MS, Ugolini V, van den Berg E, Niggemann EH, Jansen DE, Hillis LD: Smoking-induced coronary vasoconstriction in patients with atherosclerotic coronary artery disease: evidence for adrenergically mediated alterations in coronary artery tone

This is one of the reasons consumers have transitioned to e-cigarettes, or vaping, which is considered by some to be less harmful, but also to wean off traditional cigarettes