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Mitochondrial-targeted antioxidants have shown promise in reducing oxidative stress and inflammatory responses in asthma models ( Overall, these findings underscore the significant impact of mitochondrial function and dysfunction on cytokine production and inflammation in chronic lung diseases, paving the way for novel therapeutic approaches targeting mitochondrial pathways (Figure 2)

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In vitro studies have shown nicotine, cotinine and cadmium as possible culprits

Sleeping 8 hours/day was associated with an increased risk of cigarette smoking