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The review authors note that smoking reduction is a promising intervention, particularly when supported by clean nicotine, such as the nicotine used in electronic cigarettes

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The FDA issued an advisory in 2021 warning consumers not to purchase or use poppers, stating that these products can result in serious adverse health effects, including death, when ingested or inhaled. The advisory stated: The FDA has observed an increase in reports of deaths and hospitalizations with issues such as severe headaches, dizziness, increase in body temperature, difficulty breathing, extreme drops in blood pressure, blood oxygen issues (methemoglobinemia) and brain death after ingestion or inhalation of nitrite poppers. According to Adam Zmith, the author of Deep Sniff: a History of Poppers and Queer Futures, amyl nitrate, a close cousin to the chemical most widely used as poppers today, was first identified by a French chemist in 1844