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Subsequently, a signal from the nucleus to the mitochondria increases the mitochondrial stress response to maintain mitochondrial integrity by activating/remodeling the mitochondrial quality-control mechanisms responsible for the degradation of damaged/dysfunctional mitochondria (mitophagy), including the mitochondrial unfolded protein response, the dynamic mitochondrial network process, such as fission/fusion, mitochondrial biogenesis (mitogenesis), and the intracellular transfer of mitochondria