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Both the IOM and FDA have cited the necessity of examining the effects of potential MRTPs on the health of individual tobacco users and the population as a whole to determine MRTPs possible contribution to tobacco harm reduction

Subjects who used e-cigarettes or other vape products experienced: A greater increase in heart rate after vaping or smoking compared to no change for non-smokers

For example, prefilled pod kits are often made from plastic

In the US today, the sale of e-cigarettes to people under 21 is banned, and the FDA regulates every aspect of the creation, labeling, promotion, and sale of vapes (NIDA, 2020)