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Both acute and chronic pancreatitis are commonly caused by: Gallstones Drinking lots of alcohol Inherited pancreatitis, such as changes in your digestive enzyme gene called trypsin 1 (PRSS1) or your cystic fibrosis-related genes (SPINK1, CTRC, and CFTR) Some medications Acute pancreatitis causes Gallstones and heavy drinking are the most common causes for acute pancreatitis