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Our year in numbers Our Performance Metrics Number of Non-Combustible Product Consumers 1 Cigarette and HP volume share growth (bps) Cigarette and HP value share growth (bps) 2021: +20 bps Vapour (mn 10ml units/pods) HP (bn sticks) 2021:19 Cigarettes (bn sticks) 2021: 637 (Loss)/Profit from Operations (m) Revenue (m) 2021: 25,684 Revenue from New Categories (m) 2021: 2,054 Scope 1 and 2 (market-based) CO 2 e emissions(thousand tonnes) @@ % female representation in Management roles @@ 2021: 39 % reduction in waste generated 2021: 14.1 Notes: 1

Anti-Double-Stranded DNA Antibodies and Immunostimulatory Plasmid DNA in Combination Mimic the Endogenous IFN- Inducer in Systemic Lupus Erythematosus

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