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this effect appears to normalise following smoking cessation.25 Animal studies also indicate that both drugs of abuse (including nicotine) and environmental stressors appear to trigger changes in midbrain dopaminergic function.26 Consequently, prolonged smoking may act to sensitise stress response systems, weakening adaptive coping responses and making smokers more susceptible to emotional distress in response to environmental stressors

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It may alter how the liver metabolizes certain drugs, which could lead to higher or lower concentrations of the medication in the bloodstream

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