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If we then have physiological evidence to show how smoking might cause the disease, then this adds up to strong evidence that smoking does indeed cause the disease

These compounds are known carcinogens, increasing cancer risk regardless of their source

Tobacco prevention and control and is considered one of the best buys in public health, such that states with strong tobacco-control programs have demonstrated achievement of a $55 to $1 return on their investment, mostly in averted health care costs to treat smoking-related illness