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[11] Research into nicotine's most predominant metabolite, cotinine, suggests that some of nicotine's psychoactive effects are mediated by cotinine

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Simply put, even if the total amount of nicotine seems to be about the same, the way, pace and proportion of nicotine entering your body are in fact completely different

FEP When people are early in their experience with symptoms of psychosis as defined in the DSM V (excluding psychotic symptoms related to substance use or medical conditions) and early in their experience with treatment FSP Family Support Provider as defined in Administrative Rule 450:1-1-1.1