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Although interactions between pharmacokinetic drugs and tobacco smoke are primarily attributed to PAHs rather than nicotine, the latter is significantly involved in pharmacodynamic interactions through the activation of the sympathetic nervous system ( Beyond PAHs and nicotine, other substances such as acetone, pyridine, heavy metals, benzene, and CO in tobacco smoke may also interact with hepatic enzymes, albeit their impact is considered less significant (Kroon, 2007)

Its specially created to let the THC particles right on through

The extract below from tobacco company WD & HO Wills first report to the NZ government in 1991 makes interesting reading

In general, these studies suggested there were no acute changes associated with vaping, but airway resistance and conductance may be influenced by e-cigarettes