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Carcinogenic Chemicals in Tobacco Smoke Tobacco smoke constitutes more than 4,000 compounds, of which over 70 with carcinogenic activities, such as polycyclic aromatic hydrocarbons (PAHs), nitrosamines, aromatic amines, and others ( N -dimethylnitrosamine (DMN, also known as N -nitrosodimethylamine), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and N -nitrosonornicotine (NNN) ( N -nitrosamines and tobacco-specific nitrosamines (TSNAs) can attack DNA at the O6-position of guanine forming DNA adducts O6-methylguanine and O(6)-[4-oxo-4-(3-pyridyl) butyl]guanine (O6pobG)

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However, when cotinine values are assessed, they may provide insight into distinguishing true smokers from passive smokers, and passive smokers from individuals without second-hand smoke exposure