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Moreover, whole case series of vaping-related lung injury have been published without any patient experiencing a pneumothorax.32 36 Compared with this report, Jonas et al identified 8 patients with pneumothorax among 216 published cases with vaping-associated lung injury.31 In 2019, research has, for the first time, tried to identify cannabinoids in lung tissue of young adults with pneumothorax.7 While this is an important step in understanding the relationship between cannabis use and pneumothorax, evidence of cannabinoids in lung tissue does not provide proof of a pathology mechanism