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It means the cancer, that started in the breast has spread to another part of the body, commonly the liver, lungs, brain or bones

15 These techniques could be useful in clinical practice, particularly applanation tonometry, as numerous studies have shown that increased arterial stiffness as measured by aortic pulse wave velocity (PWV) and augmentation index (AIx) is directly and independently associated with increased risk of cardiovascular complications and events

Italian health ministry data from 2022 estimated that over 93,000 deaths annually in Italy were caused by smoking, and that smoking-related illness costs the countrys health service some 26 billion a year.

This works in the short run because, insidiously, the health risks of smoking do not become fully expressed for decades