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However, the use of existing pharmacotherapy in addiction treatment is limited in many cases and is often associated with several problems, including limited effectiveness, adverse reactions, narrow therapeutic index, possible overdose and illicit use of the drug, and high costs of therapy.Citation 10 - Citation 13 Currently, there are no medications approved by the US Food and Drug Administration (FDA) to treat cocaine and methamphetamine addictions

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p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T alpha-synuclein model of parkinson's disease