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E-cigarette vapor is toxic to human alveolar macrophages, inducing excessive reactive oxygen species, inflammation, apoptosis, necrosis, and impaired bacterial clearance, suggesting potential lung immune dysfunction 7

6 American Psychiatric Association

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This intervention reduced senescence-associated -galactosidase-positive (SA--Gal + ) cells, reversed lung aging, diminished neutrophil infiltration in bronchoalveolar lavage fluid, and ultimately attenuated smoke-induced alveolar enlargement, highlighting its potential value in early COPD intervention (157)