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Statistical analyses considered the drug effects on overall success rate using a logistic regression model, adjusted for bupropion-favorable polymorphism, varenicline-favorable polymorphism, gender, age, CO in exhaled air and heart rate at baseline, depression, anxiety, antidepressants/anxiolytics use, Fagerstrm test, Issa score, concomitant medications, chronic obstructive pulmonary disease, diabetes, hypertension, other diseases, and adverse events, considering bupropion monotherapy as reference