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The immune system function is also disturbed in CD patients, such as in the overactive T cell, due to this encouraging the Th1 cells by boosting the generation of the cytokines IL-12 and IFN- [60]

The sham acupuncture targeted corresponding shoulder, eye, knee, and elbow acupoints on the auricle that are unrelated to smoking cessation (29) (Figure 1)

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