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The aerosol lands in the lungs and, although some of the substances, such as nicotine, get into the bloodstream, they contain insignificant amounts of calories

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Kennedy AE, Kandalam S, Olivares-Navarrete R, Dickinson AJG (2017) E-cigarette aerosol exposure can cause craniofacial defects in Xenopus laevis embryos and mammalian neural crest cells