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Introducing warm and dry substances into the body was therefore considered key to resuscitation, leading physicians to use different stimuli to encourage the heart to resume beating

Nicotine inhibits the production of pro-inflammatory cytokines such as TNF, IL-1, and IL-6, without inhibiting the production of anti-inflammatory cytokines such as IL-10 [23]

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There was a certain amount of trial and error involved, and it sometimes took a few different combinations until the participant were happy with the outcome