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Bioavailability of nicotine from ST products is dependent on the pH of the product, since unprotonated nicotine (in more alkaline products) is absorbed more efficiently and more rapidly across the mucous membranes of the mouth than protonated forms of the drug from more acidic products

7 Psychological and Environmental Influences Psychological state and surroundings also play a role in how quickly euphoric effects are experienced

The underlying etiology of the inflammation must be determined so that appropriate treatment can be given (see Uveitis sections in Chapters 6 and 10 ).