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These stimuli activate airway epithelial cells and alveolar macrophages, leading to the release of pro-inflammatory mediators (e.g., TNF-, IL-1, IL-6) and chemokines (e.g., CXCL8, LTB4) (Figure 1), which recruit neutrophils into the airway wall, ultimately driving the inflammatory response in small airways ( + /CD8 + T lymphocytes

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Its a stretch now to imagine a time when cigarette packets werent plastered with tracheotomies and rotten toes, and smoking was something you did in offices, homes and restaurants, instead of a shameful act, furtively executed in a plastic vivarium at the airport or in a urine-scented gap between two wheelie bins, while passersby stare at you in open disgust