30 Nicotine is metabolized primarily to cotinine, which is further metabolized to trans-3-hydroxycotinine (3HC), catalyzed by the liver cytochrome P450 2A6 enzyme
Flexible Cigarette Quantities for a More Specific Preference Though the 20-cigarette pack is the most popular, companies can offer custom sizes that meet their clients' specs
3 Completely switching to e-cigs is 95% safer than smoking and can promote harm-reduction among heavy smokers In their 2018 comprehensive, systematic review, the National Academies of Sciences, Engineering and Medicine concluded ecig use is safer than smoking
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