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Airway epithelial barrier dysfunction not only impairs the physical barrier activity of airway epithelium, but further exposes sub-epithelial layers to exogenous substances, leading to a series of pathological processes such as airway inflammation, airway remodeling, airway hyperresponsiveness and increasing the rate of COPD exacerbation [7, 8]
They pointed out that a careful review of the data [from the French study] instead reveals the findings are more likely due to statistical flaws and sampling error, along with poor rates of screening and documentation of smoking history by physicians. They also expressed concern that the lead author of the French study, Jean-Pierre Changeux, had ties to the tobacco industry, having previously accepted $220,000 from the tobacco industry-funded Council for Tobacco Research in the 1990s, and collaborated with RJ Reynolds and Philip Morris. Until we have unbiased data, supported by solid research design, and free of any tobacco industry influence, we would caution against the likely myth that smoking protects from acquiring COVID-19, Maa and Halpern-Felsher wrote.
Shakhatreh MAK, Khabour OF, Alzoubi KH, Masadeh MM, Hussein EI, Bshara GN
