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Prof Sanjay Agrawal, a special adviser on tobacco at the Royal College of Physicians, said: Every cigarette smoked costs precious minutes of life, and the cumulative impact is devastating, not only for individuals but also for our healthcare system and economy

Pathways deregulated by ECA 18 W are mainly related to inflammation linked to IL-17 signaling (decreased expression of Ccl2 and Il6) (Fig