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Action : Output includes Marketing granted order letter or Marketing denial order letter Postmarket Requirements : Requires applicants to establish and maintain records and make reports that FDA requires as necessary to determine or facilitate a determination of whether there may be grounds to withdraw or temporarily suspend a marketing granted order

Fronto leaves are often sold as full, intact leaves, requiring the smoker to strip, cut, and roll them manually

Ryan Marino, MD, is a triple-board-certified physician practicing emergency medicine, medical toxicology and addiction medicine

A version of this story originally appeared in the February 2019 issue with the title "Clean."