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Whilst some non-HPHC chemical constituents have been identified in aerosols from heated tobacco products at levels higher than those observed with conventional cigarette mainstream smoke, or have been quantified in aerosols from heated tobacco products but not in conventional cigarette mainstream smoke at all, the significance of these analytical observations to the toxicological profile of heated tobacco products remains unknown and requires further investigation (St Helen et al., 2018)

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Furthermore, the presence of epicanthal folds and/or infraorbital creases or an association of the other eye findings and/or non-ocular features plus abnormal facial scars seems to denote a further distinctive gestaltic presentation of young cEDS patients, which usually attenuates or even vanishes over the years (Fig

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