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Spiders initially leapt on the nicotine gene-enabled caterpillars, but would then jump back before biting into their would-be prey, as shown in this video: When spiders encountered caterpillars whose nicotine gene was silenced, however, they would happily chow down: No nicotine traces appeared on the spider-repelling caterpillars' skin after the attack, leading the researchers to test the space around the caterpillars