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combining the freebase form of cocaine with alcohol or opioids (a combination known as a speedball) can have deadly consequences by straining both the heart and respiratory systems

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The carbon footprint of cigarette manufacturing is also on another level, forcing cigarette makers to manufacture and transport cigarettes and release large amounts of greenhouse gases

First, the scenario using the lower-bound estimates for both smokers and non-smokers, and second, the scenario comparing an average non-smoker to a lower-bound smoker