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One of the earliest studies of 684 cases describes smoking as a possible etiologic factor in bronchiogenic carcinoma (1), and another study describes tobacco as a cause of lung cancer with special reference to the infrequency of lung cancer among non-smokers (2)

Nicotine can be measured either qualitatively (whether nicotine is present) or quantitatively (how much nicotine is present) through urine, saliva, hair, or blood tests