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The product is not recommended for such animals or only according to a benefit/risk assessment by the responsible veterinarian. hypersensitivity reactions, systemic signs (such as lethargy), neurological signs (such as muscle tremors, ataxia and convulsions) and/or gastrointestinal signs (such as emesis, drooling, diarrhoea and anorexia) have been observed in dogs after administration of the veterinary medicinal product. In the advocate data sheet: There is limited experience on the use of the product in sick and debilitated animals. Vomiting can occur. Use of the product may result in transient pruritus in dogs

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Also, there are several unconfirmed candidates