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Figure 1 The ubiquitination process involves a series of enzymes: the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin ligase (E3) ( Figure 2 ( Figure 2 2 Main content 2.1 EMT and IPF EMT represents a pathophysiological process wherein ECs lose their characteristic features and take on mesenchymal properties ( 2.2 Endothelial cells and IPF Recent studies suggest that potential sources of myofibroblasts include local fibroblasts, circulating fibroblasts, tissue-resident pulmonary mesenchymal cells, and progenitor stem cells from epidermal and bone marrow sources ( 2.3 TGF- in IPF TGF-, a dimeric polypeptide growth factor ( 2.4 TGF- signal pathway in IPF TGF- signaling is pivotal in fibrogenesis, facilitating the upregulation of fibrosis-associated genes and driving EMT, which contributes to fibrosis in the lungs and kidneys (65)
Prevalence estimates were greater among males than females in all years observed
