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46, 74 Cigarette smoke extract, for instance, increased the expression of TLR4 on airway epithelial cells in vitro and induced their activation, a process that can indirectly activate the underlying DC network

it was updated in 1969 to read as it does in this ad: "Warning: The Surgeon General Has Determined that Cigarette Smoking Is Dangerous to Your Health." CNN reached out to major tobacco companies for comment about their ad campaigns during this era

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The women described encounters in which Close asked them to audition as potential nude models and spoke to them in ways they found demeaning and exploitive