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The Decline in Cigarette Consumption The combined efforts of regulatory measures, public awareness campaigns, and the rise of alternative nicotine products such as e-cigarettes have contributed to a decline in cigarette consumption in recent decades

To exclude the possibility that treatment with 5% CSE impairs cell viability, leading to the observed effects, we measured LDH release, which was not affected by CSE treatment up to a CSE concentration of 15% (Fig