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Policy responses have included banning common carrier delivery of cigarettes,[5] greater law enforcement activity on interstate roads,[6] differential tax rates near low-tax jurisdictions,[7] and cracking down on tribal reservations that sell tax-free cigarettes.[8] However, the underlying problem remains: high cigarette taxes that amount to a price prohibition of the product in many U.S

In essence, this product takes over for acetylcholine despite lacking the capability to promote the latters role in the brain

Available at: Dai X, Gakidou E, Lopez AD (2022) Evolution of the global smoking epidemic over the past half century: strengthening the evidence base for policy action

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