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While nicotine alone impacts the nervous system, elevates the risk of cardiovascular diseases, and affects brain development in the youth, the wide range of long-term impacts of ENDS is still being studied

When cruising at high altitudes, airplanes expose passengers to cosmic radiation, which emanates from outer space and interacts with Earth's atmosphere

E-cigarettes, or electronic nicotine delivery systems (ENDS), were introduced in the early 2000s as a safer alternative to smoking

Note that for simplicity, these two sensitivity analyses used models where initiation, cessation, and relapse probabilities were not stratified by subpopulation, but the results would be similar if they had been