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For instance, the anterior insular cortex can be considered a key node of the salience network (SN), and neuroimaging studies have shown that the anterior insula modulates the switching from the internally oriented default mode network (DMN) to the externally oriented executive control network (CEN) ( acting as a causal outflow hub at the junction of these large-scale brain networks ( Therefore, it is plausible to think that functional and structural disruptions of the anterior insular cortex (particularly of the right anterior insular cortex) may impair the interoceptive awareness of individuals with and their capacity to switch their attention toward more adaptive external stimuli