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In another study published in 2017, 13% of teenage girls in Nigeria had taken days off school because of period pain

These pathways may contribute to synovitis, disturb synovium-cartilage crosstalk, and promote joint degeneration in susceptible individuals, although direct OA-specific evidence remains limited, particularly for EC exposure

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According to the CDC, cigarette smoking remains the leading cause of preventable disease and death in the United States, responsible for more than 480,000 deaths per year as of 2026