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98 Studies in animal models have shown that nicotine can cause pathological effects similar to those observed with tobacco smoke such as oxidative damage and cerebrovascular impairments that lead to stroke and exacerbate ischemic injury

Source: The Lancet, 18 October 2003 US researchers investigated 3,122 patients with previous MI or stable angina and found that those who smoked were two and a half times more likely to suffer sudden cardiac death than those who had never smoked

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Cannabis strains are often bred for high THC content, which can influence their smell, resulting in that potent, sometimes skunky aroma that many associate with cannabis