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For example, aldehyde flavorings like vanillin, benzaldehyde, and cinnamaldehyde can react with PG/VG to form acetal compounds in the e-liquid, and 5080% of these acetals transfer into the aerosol (43)

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The main difference between open - and closed - system e-cigarettes is the way the e-liquid is delivered to the heating mechanism of the device

Clin Transl Oncol (2017) 19(7):799825.10.1007/s12094-016-1607-9 19 ThunMJCarterBDFeskanichDFreedmanNDPrenticeRLopezADet al50-year trends in smoking-related mortality in the United States