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It does not prove that e-cigarettes could not be of benefit if a smoker switches completely from tobacco cigarettes and uses them regularly, in the same way that FDA-approved nicotine replacement products are intended to be used. While it is generally agreed that e-cigarettes which deliver nicotine without many of the harmful products produced by burning tobacco reduce the health risks inherent in smoking cigarettes, few studies have directly investigated how useful they are in smoking cessation

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At the same time, adult smokers looking to move away from combustible cigarettes are left with fewer regulated alternatives, despite growing evidence that smokeless products can help some adults transition away from smoking

This finding provided strong evidence that tandem duplication served as a major driving force in the expansion and functional diversification of the CYP450 family in tobacco