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Nicotine Replacement Therapy (NRT) is a cost-effective intervention Any intervention to help somebody quit smoking is a cost-effective intervention, as it supports the health of the patient: 72 hours after quitting breathing may become easier and energy levels could increase 20 2-12 weeks after quitting blood circulation could improve 20 1 year after quitting the risk of heart attack has halved compared to a smoker 20 10 years after quitting the risk of lung cancer falls to around 50% of that of a smoker 20 By improving the patient's health in the long term, the costs to the NHS are also reduced 21
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Furthermore, these neuropeptides act on nonneuronal cells to stimulate the release of additional proinflammatory mediators, including ATP, adenosine, bradykinin, prostaglandins, leukotrienes, histamine, tumor necrosis factor (TNF-), interleukin-1 (IL-1), proteases, and glutamate [121]
