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To further demonstrate that the observed effects of smoking-induced aggravation of the CNV phenotype are specifically due to CD8 + T cell infiltration via the CXCL12/CXCR4 axis, we generated CD8 + T-cell-specific CXCR4 knockout ( E8i Cre

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tobacco: What science says about lighting up NEW YORK - As more states make it legal to smoke marijuana, some government officials, researchers, and others worry what that might mean for one of the country's biggest public health successes: curbing cigarette smoking