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fMRI imaging data were pre-processed using Statistical Parametric Mapping software version 12 ( The first 10 volumes of each participant were discarded to allow for T1W equilibration effects

Although many previous studies have included tobacco-related disease items as covariates in studies of tobacco and QOL, we felt that that was theoretically unsound, because the pathway from tobacco use to disease to reduced health-related QOL is a well-established causal chain